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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
30.91
Human Site:
T459
Identified Species:
45.33
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
T459
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Chimpanzee
Pan troglodytes
P60051
493
55922
T459
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
T424
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Dog
Lupus familis
XP_537306
545
61461
T510
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
T458
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Rat
Rattus norvegicus
NP_001008302
493
55958
T458
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
P397
D
K
V
S
I
V
T
P
D
D
I
L
R
L
S
Chicken
Gallus gallus
XP_419150
492
55612
T457
D
D
K
V
S
I
V
T
P
E
D
I
L
R
L
Frog
Xenopus laevis
Q6GNI6
523
60030
F464
N
D
N
K
Y
S
L
F
A
V
V
N
H
Q
G
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
D470
T
F
I
R
Q
H
K
D
Q
W
F
K
C
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
D440
V
W
F
K
F
D
D
D
E
V
S
A
V
A
T
Honey Bee
Apis mellifera
XP_395043
497
56311
T456
D
E
N
V
S
A
V
T
S
E
E
V
L
K
L
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
D434
D
E
H
V
T
V
V
D
E
E
A
I
L
K
T
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
H470
D
D
K
V
T
P
V
H
S
E
D
I
L
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
D446
S
G
K
W
I
Q
Y
D
D
D
N
P
S
M
Q
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
N465
E
N
K
W
Y
K
F
N
D
D
K
V
S
V
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
6.6
0
N.A.
0
53.3
40
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
100
26.6
0
N.A.
6.6
80
66.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
7
0
7
7
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
69
57
0
0
0
7
7
25
19
19
50
0
0
7
7
% D
% Glu:
7
13
0
0
0
0
0
0
13
63
7
0
0
0
0
% E
% Phe:
0
7
7
0
7
0
7
7
0
0
7
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
7
0
0
7
0
7
0
0
0
0
7
0
0
% H
% Ile:
0
0
7
0
13
44
0
0
0
0
7
57
0
0
0
% I
% Lys:
0
7
63
13
0
7
7
0
0
0
7
7
0
19
0
% K
% Leu:
0
0
0
0
0
0
7
0
0
0
0
7
63
7
57
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
7
7
13
0
0
0
0
7
0
0
7
7
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
7
44
0
0
7
0
0
0
% P
% Gln:
0
0
0
0
7
7
0
0
7
0
0
0
0
7
7
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
7
44
0
% R
% Ser:
7
0
0
7
50
7
0
0
13
0
7
0
13
0
7
% S
% Thr:
7
0
0
0
13
0
7
50
0
0
0
0
0
0
13
% T
% Val:
7
0
7
63
0
13
63
0
0
13
7
13
7
7
7
% V
% Trp:
0
7
0
13
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
13
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _